Endocrine Abstracts

Introduction: Hypogonadotropic hypogonadism is frequently observed in morbidly obese men, due to aromatase-dependent conversion of androgens to estrogens. The clinical impact of this sex hormone imbalance is unknown.Aim: Evaluate the clinical effects of aromatase inhibition in obesity-related hypogonadism.Methods: Double-blind, placebo-controlled, 6-month trial in severely obese men (BMI>35 kg/m2) with obesity-relate...

Background: Estrogen replacement therapy is the most effective treatment for postmenopausal (PMP) flushing, but its use is often contraindicated. An effective and safe alternative is urgently needed.Aim: To explore the effects of the LHRH receptor antagonist cetrorelix in women with severe PMP flushing who have a mean daily flush score >15.Methods: Open-label treatment with cetrorelix 250 μg twice a day in nine women with ...